Cyclic peptide natural products chart the frontier of oral bioavailability in the pursuit of undruggable targets
by Matthew R. Naylor, Andrew T. Backus, Maria-Jesus Blanco, Scott Lokey Highlights
- The pursuit of ‘undruggable’ therapeutic targets has reinvigorated interest in natural products.
- Peptides have been traditionally considered poor pharmaceutical candidates.
- Some large cyclic peptide natural products have proven bioactivity and oral bioavailability.
- Cyclic peptides have been synthesized to explore ADME optimization.