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So far Circle Pharma has created 34 blog entries.

Simple Predictive Models of Passive Membrane Permeability Incorporating Size-Dependent Membrane-Water Partition

2017-11-09T12:01:05+00:00 May 23rd, 2016|by our Team Members, Publications|

We investigate the relationship between passive permeability and molecular size, in the context of solubility-diffusion theory, using a diverse compound set with molecular weights ranging from 151 to 828, which have all been characterized in a consistent manner using the RRCK cell monolayer assay.
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Circle Pharma Announces Appointment of Co-Founder Prof. Matthew Jacobson to Department Chair

2017-09-25T12:45:19+00:00 January 19th, 2016|Press Releases|

Circle Pharma, Inc., today announced that co-founder Prof. Matthew Jacobson has been appointed Chair of the UCSF Department of Pharmaceutical Chemistry.
“This is a terrific recognition of Matt’s exceptional accomplishments as a scientist and his passionate commitment as an educator,” said David J. Earp, JD, PhD, Circle’s President and CEO. “We are very appreciative of the guidance and leadership that our two co-founders – Matt Jacobson and Scott Lokey – continue to provide to Circle.”

Circle Pharma Announces Receipt of Additional Seed Investment, and Relocation to New Laboratory Facility

2017-09-25T10:00:43+00:00 January 7th, 2016|Press Releases|

Circle Pharma, Inc., today announced that it has extended its seed funding round with an investment from ShangPharma Investment Group Limited. In conjunction with this investment, Circle has relocated to office and laboratory space in South San Francisco.

“The addition of laboratory operations to our computational chemistry platform marks the next stage of Circle’s development,” said David J. Earp, J.D., Ph.D., Circle’s President and CEO, “and we have now initiated work on Circle’s internal p […]

Starting up and spinning out: The changing nature of partnerships between pharma and academia

2017-09-19T08:55:30+00:00 September 4th, 2015|In the News|

In 2005, two chemists decided to work together to develop libraries of cyclic peptides—strings of amino acids formed in the shape of a circle—that could be used to treat a range of infectious diseases, autoimmunity and cancer. Thanks to their flexibility, these cyclic peptides can access different parts of a protein target and so bind to …

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Probing the Physicochemical Boundaries of Cell Permeability and Oral Bioavailability in Lipophilic Macrocycles Inspired by Natural Products

2017-11-09T12:12:57+00:00 May 7th, 2015|by our Team Members, Publications|

Cyclic peptide natural products contain a variety of conserved, nonproteinogenic structural elements such as d-amino acids and amide N-methylation. In addition, many cyclic peptides incorporate γ-amino acids and other elements derived from polyketide synthases.
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