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So far Circle Pharma has created 37 blog entries.

Probing the Physicochemical Boundaries of Cell Permeability and Oral Bioavailability in Lipophilic Macrocycles Inspired by Natural Products

2018-01-17T21:38:21+00:00 May 7th, 2015|by our Team Members, Publications|

Cyclic peptide natural products contain a variety of conserved, nonproteinogenic structural elements such as d-amino acids and amide N-methylation. In addition, many cyclic peptides incorporate γ-amino acids and other elements derived from polyketide synthases.
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Macrocycles and Constrained Peptides

2017-11-09T12:42:01+00:00 April 11th, 2013|on Macrocycles, Publications|

Macrocycles and constrained peptides have undergone a rebirth over the last five years in drug discovery, due mainly to the introduction of new approaches for their synthesis and screening. This scientific progress has fueled a burst of business activity, with at least 12 biotech companies in the space, of which almost half were founded in the last 5 years.
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