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Testing the conformational hypothesis of passive membrane permeability using synthetic cyclic peptide diastereomers

2019-10-09T10:18:31-08:00November 1st, 2006|by our Team Members, Publications|

Little is known about the effect of conformation on passive membrane diffusion rates in small molecules. Evidence suggests that intramolecular hydrogen bonding may play a role by reducing the energetic cost of desolvating hydrogen bond donors, especially amide N-H groups.
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