Passive Membrane Permeability in Cyclic Peptomer Scaffolds Is Robust to Extensive Variation in Side Chain Functionality and Backbone Geometry

2017-11-09T11:56:17+00:00 October 3rd, 2016|by our Team Members, Publications|

Synthetic and natural cyclic peptides provide a testing ground for studying membrane permeability in nontraditional drug scaffolds. Cyclic peptomers combine the stereochemical and geometric complexity of peptides with the functional group diversity accessible to peptoids.
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Simple Predictive Models of Passive Membrane Permeability Incorporating Size-Dependent Membrane-Water Partition

2017-11-09T12:01:05+00:00 May 23rd, 2016|by our Team Members, Publications|

We investigate the relationship between passive permeability and molecular size, in the context of solubility-diffusion theory, using a diverse compound set with molecular weights ranging from 151 to 828, which have all been characterized in a consistent manner using the RRCK cell monolayer assay.
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