A new paradigm for macrocycle drug development.

Circle Pharma operates an indication-agnostic discovery engine for the development of cell permeable macrocyclic peptide therapeutics. We deploy our computational structure-based design approach against important therapeutic targets that are challenging to address with conventional small molecules or biologics.



Enabling the full potential of macrocyclic therapeutics.

Circle aims to enable the full potential of the macrocycle peptide drug class through a design-based approach that deploys large, virtual libraries of conformationally diverse, cell permeable macrocycle scaffolds. In both Circle’s internal discovery programs and in our close collaborations with partners, our approach enables us to deliver orally bioavailable macrocyclic drug candidates and macrocyclic clinical leads against important intracellular targets.